AI-Driven Classification of Anemia and Blood Disorders Using Machine Learning Models
PDF File

Keywords

Anemia
Machine learning
Blood disorders
Clinical decision support
Hematological data

How to Cite

AI-Driven Classification of Anemia and Blood Disorders Using Machine Learning Models. (2025). Computers and Electronics in Medicine, 2(2), 43-52. https://doi.org/10.69882/adba.cem.2025073

Abstract

Anemia and other blood disorders are serious global health issues affecting millions of individuals. These conditions, often triggered by insufficient hemoglobin or red blood cells, can manifest through symptoms like fatigue, weakness, and reduced immune function. When such disorders progress into advanced stages, they can compromise organ function and overall quality of life making early diagnosis especially critical. In recent years, as the value of prompt detection has become increasingly clear, artificial intelligence (AI) and autonomous diagnostic technologies have begun to take center stage in the medical community. Machine learning models excel at parsing complex datasets and generating accurate, rapid assessments, thus offering clinicians robust decision-support tools. Through these AI-driven methods, healthcare professionals can better interpret patients’ blood metrics and clinical indicators, enabling them to identify diseases at earlier stages and develop more effective treatment strategies. This study proposes a machine learning–based approach to classify various types of anemia and related blood disorders, including iron deficiency anemia, leukemia, and thrombocytopenia. We trained five contemporary algorithms Decision Tree (DT), Random Forest (RF), CatBoost, Gradient Boosting (GB), and XGBoost using critical blood parameters such as white and red blood cell counts, hemoglobin levels, and platelet counts. Notably, Gradient Boosting emerged as the most accurate model, achieving an impressive 99.19% accuracy rate. These findings underscore how AI-powered autonomous diagnostic systems have the potential to revolutionize hematology by facilitating earlier and more precise disease detection.

PDF File

References

Alpsalaz, F., Y. Özüpak, E. Aslan, and H. Uzel, 2025. Classification of maize leaf diseases with deep learning: Performance evaluation of the proposed model and use of explicable artificial intelligence. Chemometrics and Intelligent Laboratory Systems, p. 105412.

Aruk, I., I. Pacal, and A. N. Toprak, 2025. A novel hybrid convnext-based approach for enhanced skin lesion classification. Expert Systems with Applications, p. 127721.

Asare, J. W., P. Appiahene, and E. T. Donkoh, 2023. Detection of anaemia using medical images: A comparative study of machine learning algorithms–a systematic literature review. Informatics in Medicine Unlocked, 40: 101283.

Aslan, E. and Y. Özüpak, 2024. Classification of blood cells with convolutional neural network model. Bitlis Eren Üniversitesi Fen Bilimleri Dergisi, 13: 314–326.

Awe, O. O., J. M. Adepoju, E. Boniface, and O. D. Awe, 2024. Comparative analysis of random forest and neural networks for anemia prediction in female adolescents: A lime-based explainability approach. In Practical Statistical Learning and Data Science Methods: Case Studies from LISA 2020 Global Network, USA, pp. 555–573, Springer.

Azimjonov, J. and T. Kim, 2024. Designing accurate lightweight intrusion detection systems for IoT networks using fine-tuned linear SVM and feature selectors. Computers & Security, 137: 103598.

Cakmak, Y. and I. Pacal, 2025. Enhancing breast cancer diagnosis: A comparative evaluation of machine learning algorithms using the Wisconsin dataset. Journal of Operations Intelligence, 3: 175–196.

Cakmak, Y., S. Safak, M. A. Bayram, and I. Pacal, 2024. Comprehensive evaluation of machine learning and ANN models for breast cancer detection. Computer and Decision Making: An International Journal, 1: 84–102.

Fentie, K., T. Wakayo, and G. Gizaw, 2020. Prevalence of anemia and associated factors among secondary school adolescent girls in Jimma Town, Oromia Regional State, Southwest Ethiopia. Anemia, 2020: 5043646.

Got, A., D. Zouache, A. Moussaoui, L. Abualigah, and A. Alsayat, 2024. Improved manta ray foraging optimizer-based SVM for feature selection problems: A medical case study. Journal of Bionic Engineering, 21: 409–425.

Ince, S., I. Kunduracioglu, A. Algarni, B. Bayram, and I. Pacal, 2025. Deep learning for cerebral vascular occlusion segmentation: A novel ConvNeXtV2 and GRN-integrated U-Net framework for diffusion-weighted imaging. Neuroscience, 574: 42–53.

İnce, S., I. Kunduracioglu, B. Bayram, and I. Pacal, 2025. U-Net-based models for precise brain stroke segmentation. Chaos Theory and Applications, 7: 50–60.

Islam, R., S. Tanweer, M. T. Nafis, I. Hussain, and O. Ahmad, 2024. Intelligent diagnosis of sickle cell anemia in chronic diseases through a machine learning predictive system. In International Conference on ICT for Digital, Smart, and Sustainable Development, pp. 109–124, Springer.

Jaiswal, M., A. Srivastava, and T. J. Siddiqui, 2018. Machine learning algorithms for anemia disease prediction. In Recent Trends in Communication, Computing, and Electronics: Select Proceedings of IC3E 2018, pp. 463–469, Springer.

Kaggle, 2025. Anemia types classification. [Dataset]

Karra, M. L., E. A. Rahiman, M. Narahari, A. V. Bhongir, G. Rathod, et al., 2025. Unveiling the burden of sickle cell anemia: A pilot study validating dried blood spots for newborn screening. Indian Journal of Pediatrics, 92: 405–408.

Kasthuri, E., S. Subbulakshmi, and R. Sreedharan, 2024. Insightful clinical assistance for anemia prediction with data analysis and explainable AI. Procedia Computer Science, 233: 45–55.

Kilicarslan, S., M. Celik, and Ş. Sahin, 2021. Hybrid models based on genetic algorithm and deep learning algorithms for nutritional anemia disease classification. Biomedical Signal Processing and Control, 63: 102231.

Kitaw, B., C. Asefa, and F. Legese, 2024. Leveraging machine learning models for anemia severity detection among pregnant women following ANC: Ethiopian context. BMC Public Health, 24: 3500.

Krieg, S., S. Loosen, A. Krieg, T. Luedde, C. Roderburg, et al., 2024. Association between iron deficiency anemia and subsequent stomach and colorectal cancer diagnosis in Germany. Journal of Cancer Research and Clinical Oncology, 150: 53.

Li, C., X. Shi, S. Chen, X. Peng, and S. Zong, 2025. Novel mechanistic insights into the comorbidity of anemia and rheumatoid arthritis: Identification of therapeutic targets. Molecular Immunology, 180: 74–85.

Link, H., M. Kerkmann, L. Holtmann, and M. Detzner, 2024. Anemia diagnosis and therapy in malignant diseases: Implementation of guidelines—a representative study. Supportive Care in Cancer, 32: 113.

Malak, M. Z., A. Shehadeh, A. Ayed, and E. Alshawish, 2025. Predictors of anemia among infants at the age of one year attending health centers in the West Bank/Palestine: a retrospective study. BMC Public Health, 25: 179.

Meena, K., D. K. Tayal, V. Gupta, and A. Fatima, 2019. Using classification techniques for statistical analysis of anemia. Artificial Intelligence in Medicine, 94: 138–152.

Muyama, L., A. Neuraz, and A. Coulet, 2024. Deep reinforcement learning for personalized diagnostic decision pathways using electronic health records: A comparative study on anemia and systemic lupus erythematosus. Artificial Intelligence in Medicine, 157: 102994.

Mwangi, P., S. Kotva, and O. O. Awe, 2024. Explainable AI models for improved disease prediction. In Practical Statistical Learning and Data Science Methods: Case Studies from LISA 2020 Global Network, USA, pp. 73–109, Springer.

Olatunji, S. O., M. A. A. Khan, F. Alanazi, R. Yaanallah, S. Alghamdi, et al., 2024. Machine learning-based models for the preemptive diagnosis of sickle cell anemia using clinical data. In Finance and Law in the Metaverse World: Regulation and Financial Innovation in the Virtual World, pp. 101–112, Springer.

Ozdemir, B., E. Aslan, and I. Pacal, 2025. Attention enhanced InceptionNext-based hybrid deep learning model for lung cancer detection. IEEE Access.

Ozdemir, B. and I. Pacal, 2025. A robust deep learning framework for multiclass skin cancer classification. Scientific Reports, 15: 4938.

Pacal, I., 2024a. MaxCervixT: A novel lightweight vision transformer-based approach for precise cervical cancer detection. Knowledge-Based Systems, 289: 111482.

Pacal, I., 2024b. A novel Swin Transformer approach utilizing residual multi-layer perceptron for diagnosing brain tumors in MRI images. International Journal of Machine Learning and Cybernetics, 15: 3579–3597.

Pacal, I. and O. Attallah, 2025a. Hybrid deep learning model for automated colorectal cancer detection using local and global feature extraction. Knowledge-Based Systems, p. 113625.

Pacal, I. and O. Attallah, 2025b. InceptionNext-Transformer: A novel multi-scale deep feature learning architecture for multimodal breast cancer diagnosis. Biomedical Signal Processing and Control, 110: 108116.

Pandey, M., M. Karbasi, M. Jamei, A. Malik, and J. H. Pu, 2023. A comprehensive experimental and computational investigation on estimation of scour depth at bridge abutment: Emerging ensemble intelligent systems. Water Resources Management, 37: 3745–3767.

Ramzan, M., J. Sheng, M. U. Saeed, B. Wang, and F. Z. Duraihem, 2024. Revolutionizing anemia detection: integrative machine learning models and advanced attention mechanisms. Visual Computing for Industry, Biomedicine, and Art, 7: 18.

Sanap, S. A., M. Nagori, and V. Kshirsagar, 2011. Classification of anemia using data mining techniques. In International Conference on Swarm, Evolutionary, and Memetic Computing, pp. 113–121, Springer.

Subba, S. S. and S. Araveti, 2025. Knowledge, attitudes, and practices related to iron deficiency anemia and probiotics among adolescent girls in Anantapur, India: A QIDAP-guided cross-sectional study. Food and Humanity, 4: 100551.

Yıldız, T. K., N. Yurtay, and B. Öneç, 2021. Classifying anemia types using artificial learning methods. Engineering Science and Technology, an International Journal, 24: 50–70.

Yoshida, N., 2024. Recent advances in the diagnosis and treatment of pediatric acquired aplastic anemia. International Journal of Hematology, 119: 240–247.

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.